Histone Arginine demethylases
Only one enzyme is known to show histone arginine demethylation activity in humans. It belongs to 2-oxoglutarate (2-OG)-dependent oxygenases. The mechanism involves hydroxylation of methyl group followed by deformylation.
Further reading: PMID: 16513174.Cytogenetic map of Arginine demethylases coding genes
|Enzyme (UniprotKB recommended name)||Coding gene/s||Site of histone modification|
|Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6||JMJD6||H3R2me2, H4R3me1, H4R3me2|