Histone arginine methylation
Histone arginines undergo mono (me1) or dimethylation (me2). Dimethylation can occur either in a symmetric or asymmetric manner. Symmetric dimethylation refers to methylation on 2 separate nitrogens (N,N') whereas asymmetric dimethylation means methylation that occurs on the same Nitrogen atom (N,N) present on the side chain of the arginine residue. Enzymes that catalyse these two types of dimethylation are present in 2 separate classes of arginine methyltransferases. Arginine methylation adds ~14 daltons to the overall size of the histone protein but do not perturb the charge on the residue. Methyl donor in this case is S-adenosyl-L-methionine. Histone arginine methylation is strongly associated with gene activation.
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