Monoubiquitylated H2A.Z is enriched on the inactive X chromosome in females. H2A.Z preferentially associates with H3K4me2 and H3K4me3 in the nucleosome context. H2A.Z is associated with facultative heterochromatin, and this modification marks the fraction of H2A.Z associated with gene silencing.(PMID: 17636032).

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H2AK121ub infosheet
Modified variants Histone H2A.Z
Writer/s E3 ubiquitin-protein ligase RING2
Disease associationsNo disease associations known for H2AK121ub

Sites of lysine ubiquitination H2AK119ub, H2AK121ub, H2BK120ub, H4K91ub