SFN

(STRATIFIN)

 

  • Alias                                 (According to NCBI)

 
  • HME
  • YWHAS
  • 14-3-3 protein sigma
  • 14-3-3 sigma
  • Epithelial cell marker protein 1
  • Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. p53-regulated inhibitor of G2/M progression
  • Location:1p36.11
  • Size:1315 bp
  • exons: 1
  • DNA sequence (Human):  NC_000001

  • CGH (1p36.11):  Losses (%) -1.7   Gain (%)  4.5
  • Mutations and SNPs (According to HGMD and SNP)

 

 
  • m-RNA                       (According to NCBI and CGAP)

 

  • mRNA sequence (Human):  NM_006142

  • Size: 1336 bp

  • cDNA libraries: SFN
  • Size:248 amino acids; 27774 Da
  • Catalytic activity:

  • Subcellular location: Cytoplasm. Nucleus, Secreted. Note=May be secreted by a non-classical secretory pathway.

  • Protein domains

     

  • Pathways and interactions (According to BioCarta, DIP)

  • Protein interactions: P31947
  • Clinical                            (According to OMIM, PubMed)