ABCB1

(ATP-binding cassette, sub-family B (MDR/TAP), member 1)

 

  • Alias                                 (According to NCBI)

 
  • ABC20,
  • CD243,
  • CLCS,
  • GP170,
  • MDR1,
  • MGC163296,
  • P-gp, PGY1
  • ATP-binding cassette sub-family B member 1;
  • P glycoprotein 1;
  • P-glycoprotein 1;
  • colchicin sensitivity; doxorubicin resistance;
  • multidrug resistance 1
  • Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
  • Location: 7q21.1
  • Size: 209617 bp
  • exons: 19
  • DNA sequence (Human): NC_000007.12

  • CGH (7q21.1):  Losses (%) -4.5   Gain (%)  11.2

  • Mutations and SNPs (According to HGMD and SNP)

 

 
  • m-RNA                       (According to NCBI and CGAP)

 

  • mRNA sequence (Human):  NM_000927.3

  • Size: 4872 bp

  • cDNA libraries:

  • Size: 1280 amino acids: 141463 Da
  • Catalytic activity: ATP + H(2)O + xenobiotic(In) = ADP + phosphate + xenobiotic(Out).

  • Subcellular location: Membrane; multi-pass membrane protein

  • Protein domains

     

  • Protein sequence (Human): P08183

  • Homologous genes:  55496

  • 2D PAGE:

  • 3D Structure:  

  • PTM:

  • Pathways and interactions (According to Kegg, IntAct)

 

  • Pathway: hsa02010  ABC transporters - General

                        

  • Protein interactions: ABCB1
  • Clinical                            (According to OMIM, PubMed)