• Alias                                 (According to NCBI)

• RP11-69D4.1,
• 2-ALPHA-HSD,
• 20-ALPHA-HSD,
• C9,
• DD1,
• DDH,
• DDH1,
• H-37,
• HAKRC,
• MBAB,
• MGC8954
• 20 alpha-hydroxysteroid dehydrogenase;
• aldo-keto reductase C;
• aldo-keto reductase family 1, member C1;
• chlordecone reductase homolog;
• dihydrodiol dehydrogenase 1;
• dihydrodiol dehydrogenase isoform DD1;
• hepatic dihydrodiol dehydrogenase;
• trans-1,2-dihydrobenzene-1,2-diol dehydrogenase;
• type II 3-alpha-hydroxysteroid dehydrogenase

• Description   

  (According to SwissProt)

• Converts progesterone to its inactive form, 20-alpha-dihydroxyprogesterone (20-alpha-OHP). In the liver and intestine, may have a role in the transport of bile. May have a role in monitoring the intrahepatic bile acid concentration. Has a low bile-binding ability. May play a role in myelin formation.

• Chromosomal location

  (According to NCBI, CGH: progenetix)

• Location: 10p15-p14
• Size: 14705 bp
• exons: 9
• DNA sequence (Human): NC_000010.9

• CGH (10p15):  Losses (%) -12.8   Gain (%)  2.8

• Mutations and SNPs (According to HGMD and SNP)

• HGMD :
• SNPs: 1645

• m-RNA                       (According to NCBI and CGAP)

• mRNA sequence (Human):  NM_001353.5

• Size: 1384 bp

• cDNA libraries: AKR1C1

• Protein                        (According to SwissProt, Swiss2D, PDB, dbPTM)

• Size: 323 amino acids; 36788 Da
• Catalytic activity: 17-alpha,20-alpha-dihydroxypregn-4-en-3-one + NAD(P)⁺ = 17-alpha-hydroxyprogesterone + NAD(P)H.

                                      Trans-1,2-dihydrobenzene-1,2-diol + NADP⁺ = catechol + NADPH.

• Subcellular location: Cytoplasm.

• Protein domains

• Protein sequence (Human): Q04828

• Homologous genes:  103859

• 2D PAGE: AKR1C1

• 3D Structure:  1MRQ

• PTM: AKRIC1

• Pathways and interactions (According to BioCarta, DIP)

• Pathway: AKR1C1

• Protein interactions: AKR1C1

• Tissue

  (According to GeneNote, PubMed, HPA)

• Tissue expression: PubMed Reference
• Human Protein Atlas (HPA): 

• Clinical                            (According to OMIM, PubMed)

• OMIM : 600449
• PubMed:    Early detection      Diagnosis         Prognosis        Therapy