AREG

(Amphiregulin)

 

  • Alias                                 (According to NCBI)

 
  • AR;
  • SDGF;
  • CRDGF;
  • MGC13647
  • colorectum cell-derived growth factor;
  • schwannoma-derived growth factor

  • Description   

    (According to PubMed)

  • A heparin binding, Heparin inhibited growth factor and a ligand for type-1 EGFR (Binds to and activated tyrosine kinase activity of EGFR member).This leads to production and subsequent nuclear targeting of COX-2 (Cyclooxygenase-2). It is also a growth factor for keratinocytes.It is also involved in the down regulation f E-cadherin.
  • Location: 4q13-q21
  • Size: 9874 bp
  • exons: 5
  • DNA sequence (Human): NC_000004

  • CGH (4q13-21):  Losses (%) -17.9   Gain (%)  2.2

  •  
  • Mutations and SNPs (According to HGMD and SNP)

 
  • HGMD :
  • SNPs: 374

 
  • m-RNA                       (According to NCBI and CGAP)

 

  • mRNA sequence (Human):  NM_001657

  • Size: 1270 bp

  • cDNA libraries:
  • Size: 252 amino acids; 27895 Da
  • Catalytic activity:

  • Subcellular location:

  • Protein domains

     

  • Pathways and interactions (According to Kegg, DIP)

 

                        

  • Protein interactions:

  • Clinical                            (According to OMIM, PubMed)