• Alias                                 (According to NCBI)

• AIK;
• ARK1;
• AURA;
• BTAK;
• STK6;
• STK7;
• STK15;
• AURORA2;
• MGC34538
• IPL1-related kinase;
• aurora-A;
• aurora-related kinase 1;
• aurora/IPL1-like kinase;
• breast-tumor-amplified kinase;
• serine/threonine kinase 15;
• serine/threonine kinase 6;
• serine/threonine protein kinase 15;
• serine/threonine protein kinase 6

• Description   

  (According to SwissProt)

• May play a role in cell cycle regulation during anaphase and/or telophase, in relation to the function of the centrosome/spindle pole region during chromosome segregation. May be involved in microtubule formation and/or stabilization. May play a key role during tumor development and progression.

• Chromosomal location

  (According to NCBI, CGH: progenetix)

• Location: 20q13.2-q13.3
• Size:22907 bp
• exons: 8
• DNA sequence (Human): NC_000020

• CGH (8q22):  Losses (%) -5.0   Gain (%)  19.0 

• Mutations and SNPs (According to HGMD and SNP)

• HGMD : AURKA
• SNPs: 6790

• m-RNA                       (According to NCBI and CGAP)

• mRNA sequence (Human):  

           Transcript varient 1 NM_198443

           Transcript varient 2 NM_360036

           Transcript varient 3 NM_198434

           Transcript varient 4 NM_198435

           Transcript varient 5 NM_198436

           Transcript varient 6 NM_198437

• Size:

         Transcript varient 1 2554 bp

         Transcript varient 2 2346 bp

         Transcript varient 3 2245 bp

         Transcript varient 4 2135 bp

         Transcript varient 5 2231 bp

         Transcript varient 6 2121 bp     

• cDNA libraries: AURKA

• Protein                        (According to SwissProt, Swiss2D, PDB, dbPTM)

• Size: 403 amino acids; 45809 Da
• Catalytic activity: ATP + a protein = ADP + a phosphoprotein.

• Subcellular location: Centrosome. Spindle. Note=Localizes on centrosomes in interphase cells and at each spindle pole in mitosis.

• Protein domains

• Protein sequence (Human): O14965

• Homologous genes:  2670

• 2D PAGE: AURKA

• 3D Structure:  1MQ4 2J4Z 2C6E 2C6D 2NP8 2DWB 1OL5 2BMC
                         1OL7 1MUO 2J50 1OL6

• PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. AURKA

• Pathways and interactions (According to BioCarta, PIR)

• Pathway: Role of Aurora A in mitotic spindle  regulation

• Protein interactions: AURKA

• Tissue

  (According to GeneNote, PubMed, HPA)

• Tissue expression: PubMed Reference
• Human Protein Atlas (HPA): CAB001454

• Clinical                            (According to OMIM, PubMed)

• OMIM : 603072
• PubMed:    Early detection      Diagnosis         Prognosis        Therapy