AURKB

(Aurora kinase B)

 

  • Alias                                 (According to NCBI)

 

  
  • AIK2,
  • AIM-1,
  • AIM1,
  • ARK2,
  • AurB,
  • IPL1,
  • STK12,
  • STK5
  • aurora-1;
  • aurora-B;
  • serine/threonine kinase 12
  • May be directly involved in regulating the cleavage of polar spindle microtubules and is a key regulator for the onset of cytokinesis during mitosis. Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Phosphorylates 'Ser-10' and 'Ser-28' of histone H3 during mitosis.
  • Location: 17p13.1
  • Size: 5835 bp
  • exons: 8
  • DNA sequence (Human): NC_000017.9

  • CGH (8q22):  Losses (%) -4.5  Gain (%)  10.6 
  • Mutations and SNPs (According to HGMD and SNP)

 

 
  • m-RNA                       (According to NCBI and CGAP)

 
  • Size: 344 amino acids; 39280 Da
  • Catalytic activity: ATP + a protein = ADP + a phosphoprotein.
  • Cofactor: Magnesium

  • Subcellular location: Nucleus. Centromere. Note=Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis. Colocalized with gamma tubulin in the mid-body.

  • Protein domains

     

  • Pathways and interactions (According to,IntAct)

 

  • Pathway:

                        

  • Protein interactions: AURKB
  • Clinical                            (According to OMIM, PubMed)