• Alias                                 (According to NCBI)

• BVRB,
• FLR,
• MGC117413
• flavin reductase (NADPH)

• Description   

  (According to SwissProt)

• Catalyzes electron transfer from reduced pyridine nucleotides to flavins as well as methylene blue, pyrroloquinoline quinone, riboflavin, or methemoglobin. Possible role in protecting cells from oxidative damage or in regulating iron metabolism. In the liver, converts biliverdin to bilirubin.

   

• Chromosomal location

  (According to NCBI, CGH: progenetix)

• Location: 19q13.1-q13.2
• Size: 17976 bp
• exons: 5
• DNA sequence (Human): NC_000019.8

• CGH (8q22):  Losses (%) -2.8   Gain (%)  8.9   

• Mutations and SNPs (According to HGMD and SNP)

• HGMD :
• SNPs: 645

• m-RNA                       (According to NCBI and CGAP)

• mRNA sequence (Human):  NM_000713.2

• Size: 874 bp

• cDNA libraries:

• Protein                        (According to SwissProt, Swiss2D, PDB, dbPTM)

• Size: 206 amino acids: 22119 Da
• Catalytic activity: Reduced riboflavin + NADP(+) = riboflavin + NADPH.
•                             Bilirubin + NAD(P)(+) = biliverdin + NAD(P)H.

• Subcellular location: Cytoplasm

• Protein domains

• Protein sequence (Human): P30043

• Homologous genes:  573

• 2D PAGE: BLVRB

• 3D Structure:  1HDO 1HE2 1HE3 1HE4 1HE5

• PTM: BLVRB

• Pathways and interactions (According to BioCarta, Kegg,  IntAct)

• Pathway: Kegg  hsa00860  Porphyrin and chlorophyll metabolism

                         BioCarta IL-10 Anti-inflammatory Signaling Pathway

• Protein interactions:

• Tissue

  (According to GeneNote, PubMed, HPA)

• Tissue expression: PubMed Reference
• Human Protein Atlas (HPA): 

• Clinical                            (According to OMIM, PubMed)

• OMIM : 600941
• PubMed:    Early detection      Diagnosis         Prognosis        Therapy