BMI1

(BMI1 Polycomb ring finger oncogene)

 

  • Alias                                 (According to NCBI)

 

  
  • RP11-573G6.1,
  • MGC12685,
  •  PCGF4,
  • RNF51
  • B lymphoma Mo-MLV insertion region 1 homolog; flvi-2/bmi-1;
  •  murine leukemia viral (bmi-1) oncogene homolog;
  • oncogene BMI-1;
  • polycomb group ring finger 4

 
  • Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2.
  • Location: 10p11.23
  • Size: 10049 bp
  • exons: 9
  • DNA sequence (Human): NC_000010.9

  • CGH (8q22):  Losses (%) -10.1   Gain (%)  2.8
  • Mutations and SNPs (According to HGMD and SNP)

 
  • HGMD :
  • SNPs: 648

 
  • m-RNA                       (According to NCBI and CGAP)

 

  • mRNA sequence (Human):  NM_005180.5

  • Size: 3251 bp

  • cDNA libraries:

  • Size: 326  amino acids; 36949 Da

  • Subcellular location: Nucleus. Cytoplasm.

  • Protein domains

     

  • Protein sequence (Human): P35226

  • Homologous genes:  3797

  • 2D PAGE:

  • 3D Structure:  2H0D

  • PTM: May be polyubiquitinated; which does not lead to proteasomal degradation. BMI1

 

  • Pathway:

                        

  • Protein interactions: BMI1
  • Clinical                            (According to OMIM, PubMed)