BRAF

(v-raf murine sarcoma viral oncogene homolog B1)

 

  • Alias                                 (According to NCBI)

 
  • B-RAF1,
  • BRAF1,
  • FLJ95109,
  • MGC126806,
  • MGC138284,
  • RAFB1
  • 94 kDa B-raf protein;
  • B-Raf proto-oncogene serine/threonine-protein kinase (p94);
  • Murine sarcoma viral (v-raf) oncogene homolog B1
  • Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May play a role in the postsynaptic responses of hippocampal neuron.
  • Location: 7q34
  • Size: 190283 bp
  • exons: 15
  • DNA sequence (Human): NC_000007.12

  • CGH (8q22):  Losses (%) -4.5   Gain (%)  4.5  

  • Mutations and SNPs (According to HGMD and SNP)

 
  • HGMD :
  • SNPs: 673

 
  • m-RNA                       (According to NCBI and CGAP)

 

  • mRNA sequence (Human):  NM_004333.3

  • Size: 2477 bp

  • cDNA libraries:

  • Size: 766 amino acids: 84437 Da
  • Catalytic activity: ATP + a protein = ADP + a phosphoprotein.

  • Subcellular location: Cytoplasm

  • Protein domains

     

  • Pathways and interactions (According to Kegg, IntAct)

 

  • Pathway:  hsa04010  MAPK signaling pathway
             hsa04012  ErbB signaling pathway
             hsa04150  mTOR signaling pathway
             hsa04320  Dorso-ventral axis formation
             hsa04510  Focal adhesion
             hsa04650  Natural killer cell mediated cytotoxicity
             hsa04720  Long-term potentiation
             hsa04730  Long-term depression
             hsa04810  Regulation of actin cytoskeleton
             hsa04910  Insulin signaling pathway
             hsa05210  Colorectal cancer
             hsa05211  Renal cell carcinoma
             hsa05212  Pancreatic cancer
             hsa05213  Endometrial cancer
             hsa05214  Glioma
             hsa05215  Prostate cancer
             hsa05216  Thyroid cancer
             hsa05218  Melanoma
             hsa05219  Bladder cancer
             hsa05220  Chronic myeloid leukemia
             hsa05221  Acute myeloid leukemia
             hsa05223  Non-small cell lung cancer

                        

  • Protein interactions: BRAF
  • Clinical                            (According to OMIM, PubMed)