Alias (According to NCBI)
- basigin (Ok blood group)
- 5F7,
- CD147,
- EMMPRIN,
- M6,
- OK,
- TCSF
- CD147 antigen;
- M6 leukocyte activation antigen;
- OK blood group antigen;
- basigin;
- collagenase stimulatory factor;
- extracellular matrix metalloproteinase inducer
Description
(According to SwissProt)
- Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). May target monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to plasma membranes of retinal pigment epithelium and neural retina. Seems to be a receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic processes
- Chromosomal location
(According to NCBI, CGH: progenetix)
- Location: 19p13.3
- Size: 12169 bp
- exons: 5
- DNA sequence (Human): NC_000019
CGH (8q22): Losses (%) -2.8 Gain (%) 14.0
mRNA sequence (Human): Transcript variant 1: NM_001728.2
Transcript variant2: NM_198589.1
Transcript variant3 NM_198590.1
Transcript variant4 NM_198591.1
Size: Transcript variant1: 2024 bp
Transcript variant2: 1676 bp
Transcript varient3 1766 bp
Transcript variant4 1609 bp
cDNA libraries: BSG
- Size: 385 amino acids; 42200 Da
- Subunit: Forms homooligomers in a cis-dependent manner on the plasma membrane. Forms a complex with MMP1 at the tumor cell surface. Interacts with SLC16A1 and SLC1A3; probably a BSG dimer is associated with a monocarboxylate transporter dimer. Interacts with ATP1B2, MAG and L1CAM (By similarity). Interacts with AJAP1.
Subcellular location: Cell membrane; Single-pass type I membrane protein (By similarity). Melanosome. Note=Colocalizes with SLC16A1 and SLC16A8. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Protein domains
- Pathways and interactions (According to BioCarta,PIR)
Pathway:
Protein interactions: BSG
- Tissue expression: PubMed Reference
- Human Protein Atlas (HPA): CAB002427
- OMIM : 109480
- PubMed: Early detection Diagnosis Prognosis Therapy