CD44

(CD44 antigen Indian Blood Group)

 

  • Alias                                 (According to NCBI)

 
  • IN
  • LHR
  • MC56
  • MDU2
  • MDU3
  • MIC4
  • Pgp1 -phogocyte glycoprotein
  • CDW44
  • CSPG8- chondroitin sulfate proteoglycan 8
  • HCELL- hematopoietic cell E- and L-selectin ligand
  • MUTCH-I
  • ECMR-III
  • MGC10468
  • CD44 antigen
  • CDW44 antigen
  • Hermes antigen
  • hyaluronate receptor
  • antigen gp90 homing receptor
  • heparan sulfate proteoglycan
  • extracellular matrix receptor-III
  • cell surface glycoprotein CD44
  • GP90 lymphocyte homing/adhesion receptor
  • Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events.
  • Location: 11p13
  • Size: 93533 bp
  • exons: 16
  • DNA sequence (Human): NM_000011

  • CGH (8q22):  Losses (%) -14.5   Gain (%)  4.5  

  • Mutations and SNPs (According to HGMD and SNP)

 

 
  • m-RNA                       (According to NCBI and CGAP)

 

  • mRNA sequence (Human):  NC_000610

  • Size: 5748 bp

  • cDNA libraries: cd44
  • Size:742 amino acids; 81554 Da

  • Subcellular location: Membrane; Single-pass type I membrane protein.

  • Protein domains

     

  • Protein sequence (Human): P16070

  • Homologous genes: 508

  • 2D PAGE:P16070

  • 3D Structure:1UUH, 2I83, 1P0Z

  • PTM: Glycoprotein, phosphoprotein, proteoglycan, pyrrolidone carboxylic acid CD44

  • Protein interactions: P16070
  • Clinical                            (According to OMIM, PubMed)