CDH1

(E-cadherin)

 

  • Alias                                 (According to NCBI)

 
  • UVO Uvomorulin
  • CDHE
  • ECAD
  • LCAM
  • Arc-1
  • CD324
  • Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7.
  • Location:16q22.1
  • Size: 98250 bp
  • 13 exons
  • DNA sequence (Human):  NC_00016.8. 

  • CGH (16q22.1):  Losses (%) -3.4   Gain (%)  7.8 

  • Mutations and SNPs (According to HGMD and SNP)

 

 
  • m-RNA                       (According to NCBI and CGAP)

 
  • Size:882 amino acids; 97456 Da
  • Catalytic activity: Homodimer; disulfide-linked. Interacts directly, via the cytoplasmic domain, with CTNNB1 or JUP to form the PSEN1/cadherin/catenin adhesion complex which connects to the actin skeleton through the actin binding of alpha-catenin. Interaction with PSEN1, cleaves CDH1 resulting in the disassociation of cadherin-based adherens junctions (CAJs). Interacts with AJAP1, CTNND1 and DLG7.

  • Subcellular location: Cell junction. Cell membrane; Single-pass type I membrane protein.

  • Protein domains

     

  • Pathways and interactions (According to BioCarta, PIR)

                         TGF beta signaling pathway

  • Protein interactions: 477N
  • Clinical                            (According to OMIM, PubMed)