CDH2

(Cadherin 2, type 1, N-Cadherin{neuronal})

 

  • Alias                                 (According to NCBI)

 

  
  • CD325,
  • CDHN,
  • CDw325,
  • NCAD
  • N-cadherin 1;
  • cadherin 2,
  • N-cadherin (neuronal);
  • cadherin 2, type 1; c
  • alcium-dependent adhesion protein, neuronal; neural cadherin

 
  • Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH2 may be involved in neuronal recognition mechanism.
  • Location: 18q11.2
  • Size: 226257 bp
  • exons: 14
  • DNA sequence (Human): NC_000018

  • CGH (8q22):  Losses (%) -12.3   Gain (%)  3.9  

  • Mutations and SNPs (According to HGMD and SNP)

 

 
  • m-RNA                       (According to NCBI and CGAP)

 

  • mRNA sequence (Human):  NM_001792

  • Size: 4122 bp

  • cDNA libraries: CDH2
  • Size: 906 amino acids; 99809 Da
  • Subunit: Interacts with CDCP1

  • Subcellular location: Cell membrane; Single-pass type I membrane protein.

  • Protein domains

     

  • Protein sequence (Human): P19022

  • Homologous genes:  20424

  • 2D PAGE: CDH2

  • 3D Structure:  

  • PTM:

  • Pathways and interactions (According to KEGG, IntAct)

 

                        

  • Protein interactions: CDH2
  • Clinical                            (According to OMIM, PubMed)