CDH3

(cadherin 3, type 1, P-cadherin {placental})

 

  • Alias                                 (According to NCBI)

 
  • CDHP;
  • HJMD;
  • PCAD
  • calcium-dependent adhesion protein, placental
  • Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
  • Location: 16q22.1
  • Size:54167 bp
  • exons: 13
  • DNA sequence (Human): NC_000016

  • CGH (8q22):  Losses (%) -3.4   Gain (%)  7.8 
  • Mutations and SNPs (According to HGMD and SNP)

 

 
  • m-RNA                       (According to NCBI and CGAP)

 

  • mRNA sequence (Human):NM_001793 

  • Size: 3649 bp

  • cDNA libraries: CDH3
  • Protein                        (According to SwissProt, Swiss2D )
  • Size: 829 amino acids; 91418 Da
  • Subunit structure: Interacts with CDCP1.

  • Subcellular location: Cell membrane; Single-pass type I membrane protein.

  • Protein domains

     

  • Protein sequence (Human): P22223

  • Homologous genes:  20425

  • 2D PAGE: CDH3

  • 3D Structure:  

  • PTM: Cleavage of pair of basic residues

  •          glycoprotein
  • Pathways and interactions (According to BioCarta, DIP)

 

                        

  • Protein interactions:

  • Clinical                            (According to OMIM, PubMed)