CDKN1C

(cyclin-dependent kinase inhibitor 1C (p57, Kip2))

 

  • Alias                                 (According to NCBI)

 
  • BWCR,
  • BWS,
  • KIP2,
  • WBS,
  • p57
  • cyclin-dependent kinase inhibitor 1C
  • Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life.
  • Location: 11p15.5
  • Size:2111 bp
  • exons: 2
  • DNA sequence (Human): NC_000011.8

  • CGH (8q22):  Losses (%) -11.7   Gain (%)  2.2  

  • Mutations and SNPs (According to HGMD and SNP)

 

 
  • m-RNA                       (According to NCBI and CGAP)

 

  • mRNA sequence (Human):  NM_000076.2

  • Size: 1943 bp

  • cDNA libraries:

  • Size: 316 amino acids: 32,177 Da

  • Subcellular location: Nucleus

  • Protein domains

     

  • Protein sequence (Human): P49918

  • Homologous genes:  58

  • 2D PAGE:

  • 3D Structure:  

  • PTM:

  • Pathways and interactions (According to Kegg, IntAct)

 

                        

  • Protein interactions: CDKN1C

  • Clinical                            (According to OMIM, PubMed)