CDKN2C

(cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4))

 

  • Alias                                 (According to NCBI)

 

  • INK4C,

  • p18,

  • p18-INK4C

  • CDK6 inhibitor p18;

  • OTTHUMP00000046546;

  • cyclin-dependent inhibitor; cyclin-dependent kinase 4 inhibitor C;

  • cyclin-dependent kinase 6 inhibitor p18;

  • cyclin-dependent kinase inhibitor 2C
  • Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB.
  • Location:1p32
  • Size:5943  bp
  • exons: 2
  • DNA sequence (Human): NC_000001.9

  • CGH (1p32):  Losses (%) -3.4   Gain (%)  2.2  

  • Mutations and SNPs (According to HGMD and SNP)

 

 
  • m-RNA                       (According to NCBI and CGAP)

 

  • mRNA sequence (Human):

  • Transcript variant1:  NM_001262.2

  • Transcript variant2: NM_078626.2

  • Size:

  • Transcript variant1: 2104 bp

  • Transcript variant2: 1273 bp

  • cDNA libraries:

  • Size:  168 amino acids: 18127  Da

  • Protein domains

     

 

                        

  • Protein interactions: CDKN2C
  • Clinical                            (According to OMIM, PubMed)