• Alias                                 (According to NCBI)

• Cofilin-1
• p18
• 18 kDa phosphoprotein
• Cofilin, non-muscle isoform

• Description   

  (According to SwissProt)

• Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods.

• Chromosomal location

  (According to NCBI, CGH: progenetix)

• Location: 11q13
• Size:  3523 bp
• exons: 4
• DNA sequence (Human): NC_000011. 

• CGH (11q13):  Losses (%) -3.4   Gain (%)  34.1  

• Mutations and SNPs (According to HGMD and SNP)

• HGMD :
• SNPs: CFL1

• m-RNA                       (According to NCBI and CGAP)

• mRNA sequence (Human):  NM_005507.

• Size: 1260 bp

• cDNA libraries: CFL1

• Protein                        (According to SwissProt, Swiss2D, PDB, dbPTM)

• Size: 166 amino acids;  18502 Da
• Catalytic activity:

• Subcellular location: Nucleus matrix. Cytoplasm, cytoskeleton. Note=Almost completely in nucleus in cells exposed to heat shock or 10% dimethyl sulfoxide.

• Protein domains

     

• Protein sequence (Human): P23528

• Homologous genes:  CFL1

• 2D PAGE:P23528

• 3D Structure: 1Q8G

• PTM: CFL1

• Pathways and interactions (According to BioCarta, DIP)

Pathway: CCR3 signaling in Eosinophils

                Rac 1 cell motility signaling pathway

                Rho cell motility signaling pathway

• Protein interactions: CFL1

• Tissue

  (According to GeneNote, PubMed, HPA)

• Tissue expression: PubMed Reference
• Human Protein Atlas (HPA):  CAB037077

• Clinical                            (According to OMIM, PubMed)

• OMIM : 601442
• PubMed:    Early detection      Diagnosis         Prognosis        Therapy