CKM

(Creatin kinase m-chain)

 

  • Alias                                 (According to NCBI)

 
  • CKMM
  • M-CK
  • Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.
  • Location: 19q13.2-q13.3
  • Size:  16464 bp
  • exons: 7
  • DNA sequence (Human): NC_000019.

  • CGH (8q22):  Losses (%) -2.8   Gain (%)  8.9  

  • Mutations and SNPs (According to HGMD and SNP)

 

 
  • m-RNA                       (According to NCBI and CGAP)

 

  • mRNA sequence (Human):  NM_001824.

  • Size:  1620 bp

  • cDNA libraries: CKM
  • Size:  381 amino acids;   43101 Da
  • Catalytic activity: ATP + creatine = ADP + phosphocreatine.

  • Subcellular location: Cytoplasm.

  • Protein domains

     

  • Pathways and interactions (According to BioCarta, DIP)

                                   

  • Protein interactions: CKM
  • Clinical                            (According to OMIM, PubMed)