COPS5

(COP9 constitutive photomorphogenic homolog subunit 5)

 

  • Alias                                 (According to NCBI)

 
  • CSN5
  • JAB1 Jun activation domain-binding protein
  • SGN5 Signalosome subunit 5
  • MOV-34
  • MGC3149
  • fifth protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. Interacts direclty with a large number of proteins that are regulated by the CSN complex, confirming a key role in the complex.
  • Location:8q13.2
  • Size: 19249 bp
  • exons: 8
  • DNA sequence (Human):  NC_ 000008

  • CGH (8q22):  Losses -11.3 (%)  Gain 25.1 (%)    
  • Mutations and SNPs (According to HGMD and SNP)

 

 
  • m-RNA                       (According to NCBI and CGAP)

 
  • Size:334 amino acids; 37579 Da

  • Subcellular location: Cytoplasm. Nucleus.

  • Protein domains

     

  • Protein sequence (Human): Q92905

  • Homologous genes: 55992

  • 2D PAGE: cops5

  • 3D Structure:

  • PTM: phosphorylation
  • Pathways and interactions (According to BioCarta, DIP)

  • Protein interactions: Q92905
  • Clinical                            (According to OMIM, PubMed)