CRNN

(Cornulin)

 

  • Alias                                 (According to NCBI)

 
  • Cornulin
  • DRC1
  • PDRC1
  • SEP53

  • The encoded protein contains two EF-hand Ca2+ binding domains in its N-terminus and two glutamine- and threonine-rich 60 amino acid repeats in its C-terminus. This gene, also known as squamous epithelial heat shock protein 53, may play a role in the mucosal/epithelial immune response and epidermal differentiation.

  • Survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines, attenuates deoxycholic acid (DCA)-induced apoptotic cell death and release of calcium. When overexpressed in oral squamous carcinom cell lines, regulates negatively cell proliferation by the induction of G1 arrest.
  • Location: 1q21
  • Size: 5032 bp
  • exons:
  • DNA sequence (Human):  NC_000001.10

  • CGH (1q21):  Losses (%) -1.1   Gain (%) 7.8    

  • Mutations and SNPs (According to HGMD and SNP)

 

 
  • m-RNA                       (According to NCBI and CGAP)

 

  • mRNA sequence (Human): NM_016190.2

  • Size:  1913 bp

  • cDNA libraries:
  • Size: 495 amino acids; 53533 Da
  • Catalytic activity:

  • Subcellular location: Cytoplasm

  • Protein domains

     

  • Protein sequence (Human): Q9UBG3

  • Homologous genes:

  • 2D PAGE:

  • 3D Structure:

  • PTM:

  • Pathways and interactions (According to BioCarta, DIP)

  • Pathway:

  • Protein interactions:

 
  • Clinical                            (According to OMIM, PubMed)