CTLA-4

(cytotoxic T-lymphocyte-associated protein 4)

 

  • Alias                                 (According to NCBI)

 

  
  • CD152,
  • CELIAC3,
  • CTLA-4,
  • GSE,
  • IDDM12
  • cytotoxic T-lymphocyte-associated antigen 4;
  • cytotoxic T-lymphocyte-associated serine esterase-4;
  • ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4

 
  • Possibly involved in T-cell activation. Binds to B7-1 (CD80) and B7-2 (CD86).
  • Location: 2q33
  • Size:6175 bp
  • exons: 4,3
  • DNA sequence (Human): NC_000002.10

  • CGH (2q33):  Losses (%) -5.6   Gain (%)  7.3  

  • Mutations and SNPs (According to HGMD and SNP)

 

 
  • m-RNA                       (According to NCBI and CGAP)

 

  • mRNA sequence (Human):  Transcript variant 1: NM_005214.3   

  •                                           Transcript variant 2: NM_001037631.1

  • Size: Transcript variant 1: 1988 bp

  •          Transcript variant 2: 1878 bp

  • cDNA libraries: CTLA4
  • Size: 223 amino acids; 24656 Da

  • Subcellular location: Membrane; Single-pass type I membrane protein.

  • Protein domains

     

  • Pathways and interactions (According to Kegg, DIP)

 

                        

  • Protein interactions: CTLA4
  • Clinical                            (According to OMIM, PubMed)