CTNND1

(Catenin, (Cadherin-associateed protein), delta 1)

 

  • Alias                                 (According to NCBI)

 
  • CAS,
  • CTNND,
  • KIAA0384,
  • P120CAS,
  • P120CTN,
  • p120
  • catenin, delta 1
  • Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway. May associate with and regulate the cell adhesion properties of both C- and E-cadherins. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage.
  • Location: 11q11
  • Size: 57419 bp
  • exons:
  • Transcript variant1:  18
  • Transcript variant2:  17
  • Transcript variant3:  16
  • Transcript variant4:  16
  • Transcript variant5:  17
  • Transcript variant6:  16
  • Transcript variant7:  16
  • Transcript variant8:  15
  • Transcript variant9:  14
  • Transcript variant10:15
  • Transcript variant11:14
  • Transcript variant12:14
  • Transcript vairant13:14
  • DNA sequence (Human): NC_000011.8

  • CGH (8q22):  Losses (%) -3.9   Gain (%)  4.5

  • Mutations and SNPs (According to HGMD and SNP)

 

 
  • m-RNA                       (According to NCBI and CGAP)

 

  • mRNA sequence (Human):  

  • Transcript variant1:  NM_001085458.1

  • Transcript variant2:  NM_001085459.1

  • Transcript variant3:  NM_001331.2

  • Transcript variant4:  NM_001085460.1

  • Transcript variant5:  NM_001085461.1

  • Transcript variant6:  NM_001085462.1

  • Transcript variant7:  NM_001085463.1

  • Transcript variant8:  NM_001085464.1

  • Transcript variant9:  NM_001085465.1

  • Transcript variant10:NM_001085466.1

  • Transcript variant11:NM_001085467.1

  • Transcript variant12:NM_001085468.1

  • Transcript variant13:NM_001085469.1

  • Size:

  • Transcript variant1:  6363 bp

  • Transcript variant2:  6345 bp

  • Transcript variant3:  6282 bp

  • Transcript variant4:  6185 bp

  • Transcript variant5:  6258 bp

  • Transcript variant6:  6066 bp

  • Transcript variant7:  5882 bp

  • Transcript variant8:  5864 bp

  • Transcript variant9:  5801 bp

  • Transcript variant10:5795 bp

  • Transcript variant11:5850 bp

  • Transcript variant12:5777 bp

  • Transcript variant13:5705 bp

  • cDNA libraries:

  • Size: 968 amino acids: 108170 Da
  • Catalytic activity:

  • Subcellular location: Cytoplasm. Nucleus. Cell membrane Note=Interaction with GLIS2 promotes nuclear translocation

  • Protein domains

     

  • Protein sequence (Human): O60716

  • Homologous genes:  1017

  • 2D PAGE:

  • 3D Structure:  

  • PTM: Phosphorylated

 

  • Pathway:  hsa04520  Adherens junction
             hsa04670  Leukocyte transendothelial migration

                        

  • Protein interactions: CTNND1
  • Clinical                            (According to OMIM, PubMed)