CTTN

(CORTACTIN)

Alias (According to NCBI)	Amplaxin Oncogene EMS1 FLJ34459 Src substrate cortactin
Description (According to SwissProt)	May contribute to the organization of cell structure. The SH3 motif may function as a binding region to cytoskeleton. Tyrosine phosphorylation in transformed cells may contribute to cellular growth regulation and transformation.
Chromosomal location (According to NCBI, CGH: progenetix)	Location: 11q13 Size:38047 bp exons: 15 DNA sequence (Human): NC_000011 CGH (11q13): Losses (%) -3.4 Gain (%) 34.1
Mutations and SNPs (According to HGMD and SNP)	HGMD : SNPs: 2017
m-RNA (According to NCBI and CGAP)	mRNA sequence (Human): NM_005231 Size: 3243 bp cDNA libraries: cttn
Protein (According to SwissProt, Swiss2D, PDB, UniProt)	Size: 550 amino acids; 61636 Da Subcellular location: Cytoplasm.Cell projection, lamellipodium. Cell projection, ruffle.Note=Associated with membrane ruffles and lamellipodia. Protein domains Protein sequence (Human): Q14247 Homologous genes: 3834 2D PAGE: Q14247 3D Structure: 2D1X , 1X69 PTM: SRC8
Pathways and interactions (According to BioCarta, IntAct)	Pathway: Agrin in postsynaptic differentiation Tight junction pathogenic E.coli infection Protein interactions: cttn
Tissue (According to GeneNote, PubMed, HPA)	Tissue expression: PubMed Reference Human Protein Atlas (HPA): CAB011235
Clinical (According to OMIM, PubMed)	OMIM : 164765 PubMed: Early detection Diagnosis Prognosis Therapy