• Alias                                 (According to NCBI)

• CPE1,
•  CYP2E,
• P450-J,
• P450C2E
• OTTHUMP00000046571;
• cytochrome P450 2E1;
• cytochrome P450, subfamily IIE (ethanol-inducible),
• polypeptide 1;
• flavoprotein-linked monooxygenase; microsomal monooxygenase;
• putative cytochrome P450 2E1;
•  xenobiotic monooxygenase

• Description   

  (According to SwissProt)

• Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms.

• Chromosomal location

  (According to NCBI, CGH: progenetix)

• Location: 10q24.3-qter
• Size: 11754 bp
• exons: 9
• DNA sequence (Human): NC_000010.9

• CGH (8q22):  Losses (%) -10.1   Gain (%)  1.7  

• Mutations and SNPs (According to HGMD and SNP)

• HGMD : CYP2E1
• SNPs: 1571

• m-RNA                       (According to NCBI and CGAP)

• mRNA sequence (Human):  NM_000773.3

• Size: 1667 bp

• cDNA libraries: CYP2E1

• Protein                        (According to SwissProt, Swiss2D, PDB, dbPTM)

• Size: 493 amino acids; 56849 Da
• Catalytic activity: RH + reduced flavoprotein + O₂ = ROH + oxidized flavoprotein + H₂O.

• Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

• Protein domains

• Protein sequence (Human): P05181

• Homologous genes:  68089

• 2D PAGE: CYP2E1

• 3D Structure:  

• PTM: CYP2E1

• Pathways and interactions (According to BioCarta, Kegg, PIR)

• Pathway:

          Kegg  Arachidonic acid metabolism

          Kegg  Linoleic acid metabolism

          Kegg  Metabolism of xenobiotics by cytochrome P450

          Biocarta  Mechanism of actaminophen activity and toxicity

          Biocarta  Nuclear receptors in lipid metabolism and toxicity

• Protein interactions: CYP2E1

• Tissue

  (According to GeneNote, PubMed, HPA)

• Tissue expression: PubMed Reference
• Human Protein Atlas (HPA): HPA009128

• Clinical                            (According to OMIM, PubMed)

• OMIM : 124040
• PubMed:    Early detection      Diagnosis         Prognosis        Therapy