DBC1

(deleted in bladder cancer 1)

 

  • Alias                                 (According to NCBI)

 
  • FAM5A;
  • DBCCR1
  • bA574M5.1 (deleted in bladder cancer chromosome region candidate 1 (IB3089A));
  • deleted in bladder cancer chromosome region candidate 1
  • Inhibits cell proliferation by negative regulation of the G1/S transition. Mediates cell death which is not of the classical apoptotic type and regulates expression of components of the plasminogen pathway.
  • Location: 9q32-q33
  • Size: 202832 bp
  • exons: 7
  • DNA sequence (Human): NC_000009.10

  • CGH (9q32):  Losses (%) -3.4   Gain (%)  8.9  

  • Mutations and SNPs (According to HGMD and SNP)

 

 
  • m-RNA                       (According to NCBI and CGAP)

 

  • mRNA sequence (Human):  NM_014618.2

  • Size:  3196 bp

  • cDNA libraries: DBC1
  • Size: 761 amino acids; 88760 Da

  • Subcellular location: Cytoplasm

  • Protein domains

     

  • Protein sequence (Human): O60477

  • Homologous genes:  8754

  • 2D PAGE:

  • 3D Structure:  

  • PTM: DBC1

 

  • Pathway:

                        

  • Protein interactions: DBC1
  • Clinical                            (According to OMIM, PubMed)