DCC

(deleted in colorectal carcinoma)

 

  • Alias                                 (According to NCBI)

 

  • CRC18,

  • CRCR1

  • deleted in colorectal cancer protein
  • Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.
  • Location: 18q21.3
  • Size: 1191212 bp
  • exons:
  • DNA sequence (Human): NC_000018.8

  • CGH (18q21.3):  Losses (%) -25.7   Gain (%)  1.7  

  • Mutations and SNPs (According to HGMD and SNP)

 

 
  • m-RNA                       (According to NCBI and CGAP)

 

  • mRNA sequence (Human):  NM_005215.2

  • Size: 5690 bp

  • cDNA libraries:

  • Size: 1447 amino acids: 158457 Da

  • Subcellular location: Membrane; Single-pass type I membrane protein.

  • Protein domains

     

  • Protein sequence (Human): P43146

  • Homologous genes:  21081

  • 2D PAGE:

  • 3D Structure:  

  • PTM: DCC
  • Pathways and interactions (According to Kegg, IntAct)

 

                        

  • Protein interactions: DCC
  • Clinical                            (According to OMIM, PubMed)