DSG3

(desmoglein 3 (pemphigus vulgaris antigen))

 

  • Alias                                 (According to NCBI)

 

  
  • CDHF6,
  • DKFZp686P23184,
  • PVA
  • 130-kD pemphigus vulgaris antigen;
  • desmoglein 3;
  • pemphigus vulgaris antigen

 
  • Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
  • Location: 18q12.1-q12.2
  • Size: 30934 bp
  • exons: 16
  • DNA sequence (Human): NC_000018.8

  • CGH (8q22):  Losses (%) -18.4   Gain (%)  0.6  

  • Mutations and SNPs (According to HGMD and SNP)

 

 
  • m-RNA                       (According to NCBI and CGAP)

 
  • Size: 999 amino acids; 107503 Da

  • Subcellular location: Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome

  • Protein domains

     

  • Protein sequence (Human): P32926

  • Homologous genes:  55513

  • 2D PAGE: DSG3

  • 3D Structure:  

  • PTM: Cleavage on pair of basic residues, Glycoprotein DSG3
  • Pathways and interactions (According to Kegg)

 

                        

  • Protein interactions:

  • Clinical                            (According to OMIM, PubMed)