ERBB2

(v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian))

 

  • Alias                                 (According to NCBI)

 

  • CD340,

  • HER-2,

  • HER-2/neu,

  • HER2,

  • NEU,

  • NGL,

  • TKR1,

  • c-erb B2

  • c-erb B2/neu protein;

  • erbB-2; herstatin;

  • neuroblastoma/glioblastoma derived oncogene homolog;

  • v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)
  • Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Not activated by EGF, TGF-alpha and amphiregulin.
  • Location:17q21.1
  • Size: 40523 bp
  • exons: 16 15
  • DNA sequence (Human): NC_000017.9

  • CGH (17q21.1):  Losses (%) -1.7   Gain (%)  7.8  

  • Mutations and SNPs (According to HGMD and SNP)

 

 
  • m-RNA                       (According to NCBI and CGAP)

 

  • mRNA sequence (Human):  

  • Transcript variant1: NM_004448.2

  • Transcript variant2: NM_001005862.1

  • Size:

  • Transcript variant1: 4624 bp

  • Transcript variant2: 4816 bp

  • cDNA libraries:

  • Size: 1255 amino acids: 137910 Da
  • Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

  • Subcellular location: Membrane; Single-pass type I membrane protein.

  • Protein domains

     

  • Pathways and interactions (According to Kegg, IntAct)

 

  • Pathway:  hsa04012  ErbB signaling pathway
             hsa04020  Calcium signaling pathway
             hsa04320  Dorso-ventral axis formation
             hsa04510  Focal adhesion
             hsa04520  Adherens junction
             hsa05212  Pancreatic cancer
             hsa05213  Endometrial cancer
             hsa05215  Prostate cancer
             hsa05219  Bladder cancer
             hsa05223  Non-small cell lung cancer

                        

  • Protein interactions: ERBB2
  • Clinical                            (According to OMIM, PubMed)