• Alias                                 (According to NCBI)

• HER4,
• MGC138404,
• p180erbB4
• avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4;
• receptor tyrosine-protein kinase erbB-4;
• tyrosine kinase-type cell surface receptor HER4;
• v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4;
• v-erb-a erythroblastic leukemia viral oncogene homolog 4Z

• Description   

  (According to SwissProt)

• Specifically binds and is activated by neuregulins, NRG-2, NRG-3, heparin-binding EGF-like growth factor, betacellulin and NTAK. Interaction with these factors induces cell differentiation. Not activated by EGF, TGF-A, and amphiregulin.

• Chromosomal location

  (According to NCBI, CGH: progenetix)

• Location: 2q33.3-q34
• Size:1162911bp
• exons: 14
• DNA sequence (Human): NC_000002.10

• CGH (2q33.3):  Losses (%) -6.7   Gain (%)  7.3  

• Mutations and SNPs (According to HGMD and SNP)

• HGMD : ERBB4
• SNPs: 2066

• m-RNA                       (According to NCBI and CGAP)

• mRNA sequence (Human): transcript variant JM-a/CVT-1: NM_005235.2

• transcript variant JM-a/CVT-2: NM_001042599.1

• Size:  transcript variant JM-a/CVT-1: 11941 bp

• transcript variant JM-a/CVT-2:  11893 bp 

• cDNA libraries:

• Protein                        (According to SwissProt, Swiss2D, PDB, dbPTM)

• Size: 1308 amino acids: 146808 Da
• Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

• Subcellular location: Membrane; Single-pass type I membrane protein.

• Protein domains

• Protein sequence (Human): Q15303

• Homologous genes:  21084

• 2D PAGE:

• 3D Structure:  2AHX 3BBT 3BBW  3BCE

• PTM: Ligand-binding increases phosphorylation on tyrosine residues. erbb4

• Pathways and interactions (According to BioCarta, Kegg IntAct)

• Pathway:

   KEgg  hsa04012  ErbB signaling pathway
 Kegg  hsa04020  Calcium signaling pathway
 Kegg  hsa04320  Dorso-ventral axis formation

            BioCarta    g-Secretase mediated ErbB4 Signaling Pathway

                BioCarta   Role of ERBB2 in Signal Transduction and Oncology

• Protein interactions: ERBB4

• Tissue

  (According to GeneNote, PubMed, HPA)

• Tissue expression: PubMed Reference
• Human Protein Atlas (HPA): CAB000276

• Clinical                            (According to OMIM, PubMed)

• OMIM : 600543
• PubMed:    Early detection      Diagnosis         Prognosis        Therapy