ETV4

(ets variant gene 4 (E1A enhancer binding protein, E1AF))

 

  • Alias                                 (According to NCBI)

 

  
  • E1AF;
  • PEA3;
  • E1A-F;
  • PEAS3
  • EWS protein/E1A enhancer binding protein chimera; ets variant gene 4 (E1A enhancer-binding protein, E1AF);
  • polyomavirus enhancer activator-3

 
  • Transcriptional activator that binds to the enhancer of the adenovirus E1A gene; the core-binding sequence is 5'[AC]GGA[AT]GT-3'.
  • Location: 17q21
  • Size: 18552 bp
  • exons: 12
  • DNA sequence (Human): NC_000017.9

  • CGH (8q22):  Losses (%) -1.7   Gain (%)  7.8  

  • Mutations and SNPs (According to HGMD and SNP)

 

 
  • m-RNA                       (According to NCBI and CGAP)

 

  • mRNA sequence (Human): Transcript variant 1:  NM_001986.2    

  •                                          Transcript variant 2:: NM_001079675.1

  • Size: Transcript variant 1: 2298 bp

  •          Transcript variant 2: 2431 bp

  • cDNA libraries: ETV4
  • Size: 484 amino acids; 53938 Da

  • Subcellular location: Nucleus

  • Protein domains

     

  • Protein sequence (Human): P43268

  • Homologous genes:  1504

  • 2D PAGE:

  • 3D Structure:  

  • PTM: ETV4
  • Pathways and interactions (According to BioCarta, DIP)

 

  • Pathway:

                        

  • Protein interactions: ADENO ETV4
  • Clinical                            (According to OMIM, PubMed)