• Alias                                 (According to NCBI)

• HBGF-4,
• HST,
• HST-1,
• HSTF1,
• K-FGF,
• KFGF
• fibroblast growth factor 4; heparin secretory transforming protein 1;
• human stomach cancer, transforming factor from FGF-related oncogene;
• kaposi sarcoma oncogene;
• oncogene HST;
• transforming protein KS3

• Description   

  (According to SwissProt)

• Can transform NIH 3T3 cells from a human stomach tumor (hst) and from karposi's sarcoma (KS3). It has a mitogenic activity.

• Chromosomal location

  (According to NCBI, CGH: progenetix)

• Location: 11q13.3
• Size: 2375 bp
• exons: 3
• DNA sequence (Human):NC_000011.8

• CGH (11q13.3):  Losses (%) -3.4   Gain (%)  34.1  

• Mutations and SNPs (According to HGMD and SNP)

• HGMD :
• SNPs: 2249

• m-RNA                       (According to NCBI and CGAP)

• mRNA sequence (Human):  NM_002007.1

• Size: 1219 bp

• cDNA libraries:

• Protein                        (According to SwissProt, Swiss2D, PDB, dbPTM)

• Size: 206 amino acids: 22048 Da
• Protein domains

     

• Protein sequence (Human): P08620

• Homologous genes:  1522

• 2D PAGE:

• 3D Structure:  1IJT

• PTM: FGF4

• Pathways and interactions (According to Kegg, PIR)

• Pathway:

  MAPK signaling pathway
  Regulation of actin cytoskeleton
  Melanoma

• Protein interactions: FGF4

• Tissue

  (According to GeneNote, PubMed, HPA)

• Tissue expression: PubMed Reference
• Human Protein Atlas (HPA):  HPA011209

• Clinical                            (According to OMIM, PubMed)

• OMIM : 164980
• PubMed:    Early detection      Diagnosis         Prognosis        Therapy