FN1

(Fibronectin)

 

  • Alias                                 (According to NCBI)

 
  • Fibronectin
  • FN
  • CIG
  • FNZ
  • MSF
  • ED-B
  • FINC
  • GFND
  • LETS
  • GFND2

  • Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape.Anastellin binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling.
  • Location: 2q34
  • Size: 75616 bp
  • exons:
  • DNA sequence (Human):  NG_012196.1

  • CGH (2q34):  Losses (%) -5.6   Gain (%) 5.6    

  • Mutations and SNPs (According to HGMD and SNP)

 
  • HGMD :
  • SNPs: FN1

 
  • m-RNA                       (According to NCBI and CGAP)

 
  • Size: 2386 amino acids; 262625 Da
  • Catalytic activity:

  • Subcellular location: Secreted › extracellular space › extracellular matrix

  • Protein domains

     

  • Protein sequence (Human): P02751

  • Homologous genes:

  • 2D PAGE:

  • 3D Structure:1FNA

  • PTM:

  • Pathways and interactions (According to BioCarta, DIP)

  • Pathway:

  • Protein interactions: P02751
  • Clinical                            (According to OMIM, PubMed)