FOS

(v-fos FBJ murine osteosarcoma viral oncogene homolog)

 

  • Alias                                 (According to NCBI)

 
  • AP-1,
  • C-FOS
  • FBJ murine osteosarcoma viral (v-fos) oncogene homolog (oncogene FOS);
  • activator protein 1;
  • cellular oncogene c-fos
  • Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, c-fos and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation.
  • Location: 14q24.3
  • Size:3383  bp
  • exons: 4
  • DNA sequence (Human): NC_000014.7

  • CGH (14q24.3):  Losses (%) -2.8   Gain (%)  8.9  

  • Mutations and SNPs (According to HGMD and SNP)

 

 
  • m-RNA                       (According to NCBI and CGAP)

 

  • mRNA sequence (Human): NM_005252

  • Size: 2084 bp

  • cDNA libraries: FOS
  • Size: 380 amino acids; 40695 Da
  • Subunit: Heterodimer with JUN. Interacts with DSIPI; this interaction inhibits the binding of active AP1 to its target DNA. Interacts with MAFB

  • Subcellular location: Nucleus

  • Protein domains

     

 

                        

  • Clinical                            (According to OMIM, PubMed)