FSCN1

(fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)

 

  • Alias                                 (According to NCBI)

 

  
  • FLJ38511,
  • SNL,
  • p55
  • Singed, drosophila, homolog-like;
  • actin bundling protein; fascin 1;
  • singed-like (fascin homolog, sea urchin)

 
  • Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Probably involved in the assembly of actin filament bundles present in microspikes, membrane ruffles, and stress fibers.
  • Location: 7p22
  • Size: 13833 bp
  • exons: 5
  • DNA sequence (Human): NC_000007.1

  • CGH (7p22):  Losses (%) -0.6   Gain (%)  11.7  

  • Mutations and SNPs (According to HGMD and SNP)

 

 
  • m-RNA                       (According to NCBI and CGAP)

 
  • Size:493 amino acids; 54530 Da
  • Subunit: Associates with beta-catenin

  • Protein domains

     

  • Protein sequence (Human): Q16658

  • Homologous genes:  48164

  • 2D PAGE: FSCN1

  • 3D Structure:  1DFC

  • PTM: Phosphorylation on Ser-39 inhibits the actin-binding ability of fascin. FSCN1
  • Pathways and interactions (According to IntAct)

 

  • Pathway:

                        

  • Protein interactions: FSCN1
  • Clinical                            (According to OMIM, PubMed)