• Alias                                 (According to NCBI)

• RP1-66H14.1,
• MGC45350,
• SLK,
• SYN
• OKT3-induced calcium influx regulator;
• c-syn protooncogene; protein-tyrosine kinase fyn;
• proto-oncogene tyrosine-protein kinase fyn;
• src-like kinase;
• src/yes-related novel;
• tyrosine kinase p59fyn(T)

• Description   

  (According to SwissProt)

• Implicated in the control of cell growth. Plays a role in the regulation of intracellular calcium levels, with isoform 2 showing the greater ability to mobilize cytoplasmic calcium in comparison to isoform 1. Required in brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and neurite extension. Blocks axon outgrowth and attraction induced by NTN1 by phosphorylating its receptor DDC.

• Chromosomal location

  (According to NCBI, CGH: progenetix)

• Location: 6q21
• Size: bp
• exons:
• DNA sequence (Human):

• CGH (6q21):  Losses (%) -5.6   Gain (%)  3.9  

• Mutations and SNPs (According to HGMD and SNP)

• HGMD :
• SNPs: 2534

• m-RNA                       (According to NCBI and CGAP)

• mRNA sequence (Human):  

• Size: bp

• cDNA libraries:

• Protein                        (According to SwissProt, Swiss2D, PDB, dbPTM)

• Size: 537 amino acids: 60762 Da
• Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

• Subcellular location:

  Cell membrane. Note=Present and active in lipid rafts. Present in cell body and along the process of mature and developing oligodendroyctes.

• Protein domains

     

• Protein sequence (Human): P06241

• Homologous genes:  48068

• 2D PAGE:

• 3D Structure:  1A0N 1AOT 1AOU 1AVZ 1AZG 1EFN 1FYN 1G83 1M27 1NYF 1NYG 1SHF 1ZBJ 2DQ7

• PTM: FYN

• Pathways and interactions (According to BioCarta, Kegg,  IntAct)

• Pathway: Kegg hsa04360  Axon guidance
        Kegg hsa04510  Focal adhesion
        Kegg hsa04520  Adherens junction
        Kegg hsa04650  Natural killer cell mediated cytotoxicity
        Kegg hsa04660  T cell receptor signaling pathway
        Kegg hsa04664  Fc epsilon RI signaling pathway
        Kegg hsa05130  Pathogenic Escherichia coli infection - EHEC
        Kegg hsa05131  Pathogenic Escherichia coli infection - EPEC

                          BioCarta  Bioactive Peptide Induced Signaling Pathway

                                  BioCarta  Eph Kinases and ephrins support platelet aggregation

                                  BioCarta  Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia

                                  BioCarta  IL-7 Signal Transduction

                                  BioCarta  Integrin Signaling Pathway

                                  BioCarta  Lck and Fyn tyrosine kinases in initiation of TCR Activation

                                  BioCarta  Reelin Signaling Pathway

                                  BioCarta  T Cell Receptor Signaling Pathway

                                  BioCarta  TSP-1 Induced Apoptosis in Microvascular Endothelial Cell

• Protein interactions: FYN

• Tissue

  (According to GeneNote, PubMed, HPA)

• Tissue expression: PubMed Reference
• Human Protein Atlas (HPA): CAB005034

• Clinical                            (According to OMIM, PubMed)

• OMIM : 137025
• PubMed:    Early detection      Diagnosis         Prognosis        Therapy