GNLY

(Granulysin)

 

  • Alias                                 (According to NCBI)

 

  
  • 519;
  • LAG2;
  • NKG5;
  • LAG-2;
  • D2S69E;
  • TLA519
  • T-lymphocyte activation gene 519;
  • lymphocyte-activation gene 2
  • Antimicrobial protein that kills intracellular pathogens. Active against a broad range of microbes, including Gram-positive and Gram-negative bacteria, fungi, and parasites. Kills Mycobacterium tuberculosis.
  • Location: 2p11.2
  • Size: 4462 bp
  • exons: 5
  • DNA sequence (Human): NC_000002.10

  • CGH (2p11.2):  Losses (%) -1.7   Gain (%)  4.5  

  • Mutations and SNPs (According to HGMD and SNP)

 

 
  • m-RNA                       (According to NCBI and CGAP)

 

  • mRNA sequence (Human):  

  • Transcript variant 519: NM_012483.2

  • Transcript variant NKG5: NM_006433.3

  • Size:

  • Transcript variant 519:  995 bp

  • Transcript variant NKG5: 751 bp

  • cDNA libraries:

  • Size: 145 amino acids: 16374 Da

  • Subcellular location: Secreted. Note=Located in the cytotoxic granules of T-cells, which are released upon antigen stimulation.

  • Protein domains

     

  • Protein sequence (Human): P22749

  • Homologous genes:  88739

  • 2D PAGE:

  • 3D Structure:  1L9L

  • PTM: A 9 kDa form is produced by proteolytic processing of a 15 kDa protein. GNLY

 

  • Pathway:

                        

  • Protein interactions:

  • Clinical                            (According to OMIM, PubMed)