NDC80

(NDC80 homolog, kinetochore complex component (S. cerevisiae))

 

  • Alias                                 (According to NCBI)

 

  
  • HEC,
  • HEC1,
  • KNTC2,
  • TID3,
  • hsNDC80
  • highly expressed in cancer,
  • rich in leucine heptad repeats;
  • kinetochore associated 2
  • Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore.
  • Location: 18p11.32
  • Size: 45025 bp
  • exons: 15
  • DNA sequence (Human): NC_000018.8

  • CGH (18q11.32):  Losses (%) -4.5   Gain (%)  11.2  

  • Mutations and SNPs (According to HGMD and SNP)

 

 
  • m-RNA                       (According to NCBI and CGAP)

 

  • mRNA sequence (Human):  NM_006101.1

  • Size: 2150 bp

  • cDNA libraries:

  • Size: 642 amino acids: 73913 Da

  • Subcellular location: Nucleus. Kinetochore. Note=Localizes to kinetochores from late prophase to anaphase. Localizes specifically to the outer plate of the kinetochore.

  • Protein domains

     

  • Protein sequence (Human): O14777

  • Homologous genes:  38141

  • 2D PAGE:

  • 3D Structure:  2IGP 2VE7

  • PTM: Phosphorylation begins in S phase of the cell cycle and peaks in mitosis. Phosphorylated by NEK2. May also be phosphorylated by AURKA and AURKB.

 

  • Pathway:

                        

  • Protein interactions: NDC80
  • Clinical                            (According to OMIM, PubMed)