HIST4H4

(histone cluster 4, H4)

 

  • Alias                                 (According to NCBI)

 
  • H4/p,
  • MGC24116
  • histone 4, H4;
  • histone H4
  • Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
  • Location: 12p12.3
  • Size: 412 bp
  • exons: 1
  • DNA sequence (Human): NC_000012.10

  • CGH (12p12.3):  Losses (%) -5.0   Gain (%)  7.3    

  • Mutations and SNPs (According to HGMD and SNP)

 

 
  • m-RNA                       (According to NCBI and CGAP)

 

  • mRNA sequence (Human):  NM_175054.2

  • Size: 412 bp

  • cDNA libraries:

  • Size: 103 amino acids: 11367 Da

  • Subcellular location: Nucleus

  • Protein domains

     

 

  • Pathway:

                        

  • Clinical                            (According to OMIM, PubMed)