HMGA2

(high mobility group AT-hook 2)

 

  • Alias                                 (According to NCBI)

 
  • BABL,
  • HMGI-C,
  • HMGIC,
  • LIPO,
  • STQTL9
  • High-mobility group protein HMGI-C;
  • high-mobility group (nonhistone chromosomal) protein isoform I-C
  • Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2.
  • Location: 12q15
  • Size: 141832 bp
  • exons:
  • Transcript vairant1: 4
  • Transcript vairant2: 3
  • DNA sequence (Human): NC_000012.10

  • CGH (12q15):  Losses (%) -2.2   Gain (%)  8.9  

  • Mutations and SNPs (According to HGMD and SNP)

 

 
  • m-RNA                       (According to NCBI and CGAP)

 

  • mRNA sequence (Human):

  • Transcript vairant1:  NM_003483.4

  • Transcript variant2: NM_003484.1

  • Size:

  • ranscript vairant1: 4150 bp

  • ranscript vairant2: 1539 bp

  • cDNA libraries:

  • Size: 109 amino acids: 11832 Da

  • Subcellular location: Nucleus.

  • Protein domains

     

  • Protein sequence (Human): P52926

  • Homologous genes:  2602

  • 2D PAGE:

  • 3D Structure:  

  • PTM: Regulated by cell cycle-dependent phosphorylation which alters its DNA binding affinity.HMGA2

 

  • Pathway:

                        

  • Protein interactions: HMGA2
  • Clinical                            (According to OMIM, PubMed)