HMMR

(Hyaluronan-mediated motility receptor)

 

  • Alias                                 (According to NCBI)

 
  • hyaluronan-mediated motility receptor
  • CD168
  • IHABP
  • RHAMM

  • The protein encoded by this gene is involved in cell motility. It is expressed in breast tissue and together with other proteins, it forms a complex with BRCA1 and BRCA2, thus is potentially associated with higher risk of breast cancer. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

  • When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including the focal adhesion kinase occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular-regulated kinase (ERK) activity
  • Location: 5q33.2
  • Size: 31435 bp
  • exons:
  • DNA sequence (Human):  NG_023309.1

  • CGH (5q33.2):  Losses (%) -15.1   Gain (%) 1.7    

  • Mutations and SNPs (According to HGMD and SNP)

 

 
  • m-RNA                       (According to NCBI and CGAP)

 
  • Size: 724 amino acids; 84100 Da
  • Catalytic activity:

  • Subcellular location: Cytoplasm, Cell Surface

  • Protein domains

     

  • Protein sequence (Human): O75330

  • Homologous genes:

  • 2D PAGE:

  • 3D Structure:

  • PTM:

  • Pathways and interactions (According to BioCarta, DIP)

  • Pathway:

  • Protein interactions:

  • Clinical                            (According to OMIM, PubMed)