HOPX

Homeodomain-only protein

 

  • Alias                                 (According to NCBI)

 
  • Cameo
  • LAGY
  • MGC20820
  • NECC1
  • OB1
  • SMAP31
  • Toto
  • heart odd homeobox 1 protein
  • lung cancer-associated Y protein
  • not expressed in choriocarcinoma clone 1
  • Homeodomain-only protein

  • The protein encoded by this gene is a homeodomain protein that lacks certain conserved residues required for DNA binding. It was reported that choriocarcinoma cell lines and tissues failed to express this gene, which suggested the possible involvement of this gene in malignant conversion of placental trophoblasts. Studies in mice suggested that this protein may interact with serum response factor (SRF) and modulate SRF-dependent cardiac-specific gene expression and cardiac development. Multiple alternatively spliced transcript variants encoding the same protein have been observed, the full-length natures of only some have been determined.
  • Location: 4q11-q12
  • Orientation: minus  strand
  • Size: 33,680  bp
  • 3  exons
  • DNA sequence (Human):  NC_000004


  • CGH (4q11-12):  Losses (%) -14.5  Gain (%) 0.6  
  • Mutations and SNPs (According to HGMD and SNP)
  • HGMD :
  • SNPs: HOP
  • m-RNA                       (According to NCBI and CGAP)

 
  • Size: 73 amino acids; 8272 Da  
  • Catalytic activity:

  • Subcellular location: Nuclear

  • Protein domains

 

  • Protein sequence (Human): Q9BPY8

  • Homologous genes: HOP

  • 2D PAGE:Q9BPY8

  • 3D Structure:

  • PTM: HOP
  • Pathways and interactions (According to BioCarta, DIP)

  • Pathway:

                        Hop Pathway in Cardiac Development

  • Protein interactions:

 
  • Clinical                            (According to OMIM, PubMed)