IL8

(InterLeukine 8)

 

  • Alias                                 (According to NCBI)

 
  • K60;
  • NAF;
  • GCP1;
  • LECT;
  • LUCT;
  • NAP1; neutrophil-activating peptide 1
  • 3-10C;
  • CXCL8;
  • GCP-1;
  • LYNAP; lymphocyte-derived neutrophil-activating factor
  • MDNCF; monocyte-derived neutrophil chemotactic factor
  • MONAP;
  • SCYB8; small inducible cytokine subfamily B, member 8
  • TSG-1;
  • AMCF-I;
  • b-ENAP
  • emoctakin
  • T cell chemotactic factor
  • chemokine (C-X-C motif) ligand 8
  • beta-thromboglobulin-like protein
  • granulocyte chemotactic protein 1
  • IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively.
  • Location: 4q13-q21
  • Size: 3159 bp
  • exons: 4
  • DNA sequence (Human): NC_000004

  • CGH (4q13):  Losses (%) -17.9   Gain (%)  2.2  

  • Mutations and SNPs (According to HGMD and SNP)

 

 
  • m-RNA                       (According to NCBI and CGAP)

 

  • mRNA sequence (Human):  NM_000584

  • Size: 1666 bp

  • cDNA libraries: il8
  • Size:99 amino acids; 11098 Da

  • Subcellular location: secreted

  • SUBUNIT: Homodimer.

  • Protein domains

     

  • Protein sequence (Human): P10145

  • Homologous genes:  47937

  • 2D PAGE:il8

  • 3D Structure:  3IL8 1ICW 1QE6 1ILQ 1ILP 1ROD 1IKL 1IKM
         1IL8 2IL8

  • PTM: Several N-terminal processed forms are produced by proteolytic cleavage after secretion from at least peripheral blood monocytes, leukcocytes and endothelial cells. In general, IL-8(1-77) is referred to as interleukin-8. IL-8(6-77) is the most promiment form    IL8
  • Clinical                            (According to OMIM, PubMed)