INHBA

(inhibin, beta A)

 

  • Alias                                 (According to NCBI)

 

  
  • FSH-releasing protein;
  • Inhibin, beta-1;
  • erythroid differentiation factor;
  • follicle-stimulating hormone-releasing protein;
  • inhibin beta A;
  • inhibin, beta A (activin A, activin AB alpha polypeptide)
  • EDF,
  • FRP

 
  • Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
  • Location: 7p15-p13
  • Size: 14106 bp
  • exons: 2
  • DNA sequence (Human): NC_000007.12

  • CGH (7q15-p13):  Losses (%) -1.1   Gain (%)  13.4  

  • Mutations and SNPs (According to HGMD and SNP)

 

 
  • m-RNA                       (According to NCBI and CGAP)

 
  • Size:  426 amino acids; 47442 Da
  • Catalytic activity:

  • Subcellular location: Secreted

  • Protein domains

     

  • Pathways and interactions (According to Kegg, DIP)

 

                        

  • Protein interactions: INHBA
  • Clinical                            (According to OMIM, PubMed)