• Alias                                 (According to NCBI)

• AP1

• c-Jun

• Description   

  (According to SwissProt)

• Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'.

• Chromosomal location

  (According to NCBI, CGH: progenetix)

• Location:1p32-p31
• Size: 3323 bp
• exons: 1
• DNA sequence (Human):  NC_000001

• CGH (8q22):  Losses (%) -3.4  Gain (%) 2.2     

• Mutations and SNPs (According to HGMD and SNP)

• HGMD :
• SNPs: 3725

• m-RNA                       (According to NCBI and CGAP)

• mRNA sequence (Human):  NM_002228.

• Size:  3338 bp

• cDNA libraries: jun

• Protein                        (According to SwissProt, Swiss2D, PDB, dbPTM)

• Size:331 amino acids; 35676 Da

• Subcellular location: Nucleus

• Protein domains

     

• Protein sequence (Human): P05412

• Homologous genes: 1679

• 2D PAGE: jun

• 3D Structure:  jun

• PTM:  JUN

• Pathways and interactions (According to BioCarta, DIP)

       Pathway:

• MApkinase signalling pathway Biocarta, Kegg

• Toll like receptor signaling pathway Biocarta, Kegg

• TCR signaling pathway Biocarta, Kegg

• BCR signaling pathway Biocarta, Kegg

• ErbB signaling pathway Kegg hsa04012

• Wnt signaling pathway Kegg hsa04310 

• focal adhesion hsa04510

• GnRH signaling pathway hsa04912

• Epithelial cell signaling in Helicobacter pylori infection Kegg hsa05120

• Colorectal cancer Kegg hsa05210

• Renal cell carcinoma Kegg hsa05211

• biocarta:-

• Agrin in Postsynaptic Differentiation

• Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling

• ATM Signaling Pathway

• Cadmium induces DNA synthesis and proliferation in macrophages

• D4-GDI Signaling Pathway

• EGF Signaling Pathway

• EPO Signaling Pathway

• FAS signaling pathway ( CD95 )

• Fc Epsilon Receptor I Signaling in Mast Cells

• Hypoxia-Inducible Factor in the Cardiovascular System

• IGF-1 Signaling Pathway

• IL 2 signaling pathway

• IL 6 signaling pathway

• IL12 and Stat4 Dependent Signaling Pathway in Th1 Development

• Inhibition of Cellular Proliferation by Gleevec

• Insulin Signaling Pathway

• Integrin Signaling Pathway

• Links between Pyk2 and Map Kinases

• Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha)

• METS affect on Macrophage Differentiation

• Nerve growth factor pathway (NGF)

• Oxidative Stress Induced Gene Expression Via Nrf2

• PDGF Signaling Pathway

• Pertussis toxin-insensitive CCR5 Signaling in Macrophage

• Repression of Pain Sensation by the Transcriptional Regulator DREAM

• Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy

• Signal transduction through IL1R

• Signaling Pathway from G-Protein Families

• The 4-1BB-dependent immune response

• The information-processing pathway at the IFN-beta enhancer

• TNF/Stress Related Signaling

• TNFR1 Signaling Pathway

• TPO Signaling Pathway

• TSP-1 Induced Apoptosis in Microvascular Endothelial Cell

Protein interactions: P05412

• Tissue

  (According to GeneNote, PubMed, HPA)

• Tissue expression: PubMed Reference
• Human Protein Atlas (HPA): CAB003801

• Clinical                            (According to OMIM, PubMed)

• OMIM : 165160
• PubMed:    Early detection      Diagnosis         Prognosis        Therapy