- Alias
- HNP
- NRPN
- PRSS19
- TADG14
- neuropsin
- ovasin
- Weakly similar to protease M [H.sapiens]
- kallikrein 8 (neuropsin/ovasin)
- protease, serine, 19
- tumor-associated differentially expressed gene 14
- Neuropsin precursor (EC 3.4.21.-) (NP) (Kallikrein 8) (Ovasin) (Serine
protease TADG-14)
(Tumor-associated differentially expressed gene-14 protein) (UNQ283/PRO322).
- Description
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in four transcript variants encoding four different isoforms. The isoforms exhibit distinct patterns of expression that suggest roles in brain plasticity and ovarian cancer.
- Chromosomal location
(According to LocusLink,
- Location: 19q13.3-q13.4
- Orientation: Minus strand
- Size: 5,694 bases
- 6 Exons
- DNA Sequence: NT_011109
- CGH ( 19q13.3-q13.4 ) : Loss (%) -2.2 Gain (%) 10.1
- Amplifications
- Identification and overexpression of human neutrophil alpha-defensins (human neutrophil peptides 1, 2 and 3) in squamous cell carcinomas of the human tongue.
- Immunohistochemical staining of human alpha-defensin-1 (HNP-1), in the submandibular glands of patients with oral carcinomas.
- Defensin-1, an antimicrobial peptide present in the saliva of patients with oral diseases.
- Defensin-1, a peptide detected in the saliva of oral squamous cell carcinoma patients.
- Mutations and SNPs
- m-RNA
- m-RNA Sequence: 4 Transcript variants: NM_007196, NM_144505, NM_144506, NM_144507
- c-DNA Libraries: KLK8
- Protein(According to SwissProt)
- Size: 260 amino acids; 28048 Da
- Sub cellular location: Secreted
- Catalytic activity: preferential cleavage: Arg-, Lys-
- Protein domains:
- Protein sequence: O60259
- Homologous genes: KLK8
- Pathways and interactions
- Pathways:
- Interactions:
- Tissue
(According to GeneNote
expression array results)
- Clinical
- OMIM:605644
- Ovarian cancer: Human kallikrein 8 (hK8/TADG-14) expression is associated with an early clinical stage and favorable prognosis in ovarian cancer.
- Cervical cancer: The novel serine protease tumor-associated differentially expressed gene-14 (KLK8/Neuropsin/Ovasin) is highly overexpressed in cervical cancer.
- Breast cancer: Kallikrein gene downregulation in breast cancer.