KRT18

(Keratin 18)

 

  • Alias                                 (According to NCBI)

 
  • Keratin 18
  • K18
  • Cytokeratin 18
  • cell proliferation-inducing protein 46
  • CYK18
  • KRT18

  • KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis.

  • Involved in the uptake of thrombin-antithrombin complexes by hepatic cells By similarity. When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.
  • Location: 12q13
  • Size: 4031 bp
  • exons:
  • DNA sequence (Human):  NG_008351.1

  • CGH (12q13):  Losses (%) -1.7   Gain (%) 8.4  

  • Mutations and SNPs (According to HGMD and SNP)

 

 
  • m-RNA                       (According to NCBI and CGAP)

 
  • Size: 430 amino acids; 48058 Da
  • Catalytic activity:

  • Subcellular location: Cytoplasm, perinuclear region

  • Protein domains

     

  • Protein sequence (Human): P05783

  • Homologous genes:

  • 2D PAGE: P05783

  • 3D Structure:

  • PTM: KRT18
  • Pathways and interactions (According to BioCarta, DIP)

  • Pathway:

  • Protein interactions: DIP
  • Clinical                            (According to OMIM, PubMed)