LAMC2

(Laminin, gamma 2)

 

  • Alias                                 (According to NCBI)

 
     
  • laminin, gamma 2
  • B2T;
  • CSF cell-scattering factor (140kDa);
  • EBR2;
  • BM600;
  • EBR2A;
  • LAMB2T;
  • LAMNB2;
  • MGC138491;
  • MGC141938
  • epiligrin
  • BM600-100kDa
  • nicein-100kDa
  • kalinin-105kDa
  • kalinin (105kD)
  • ladsin (140kDa)
  • nicein (100kDa)
  • Herlitz junctional epidermolysis bullosa
  • Large adhesive scatter factor 140 kDa subunit
  • Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Ladsin exerts cell-scattering activity toward a wide variety of cells, including epithelial, endothelial, and fibroblastic cells.
  • Location: 1q25-q31
  • Size:59089 bp
  • exons: 20
  • DNA sequence (Human): NC_000001

  • CGH (1q25):  Losses (%) -1.1   Gain (%)  9.5  

  • Mutations and SNPs (According to HGMD and SNP)

 

 
  • m-RNA                       (According to NCBI and CGAP)

 

  • mRNA sequence (Human):  Isoform A NM_005562 , Isoform B NM_018891

  • Size: Isoform A 5623 bp

  •          Isoform B  4522 bp

  • cDNA libraries: Lamc2
  • Size: 1193 amino acids; 130976 Da
  • Catalytic activity:

  • Subcellular location: Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component.

  • Protein domains

     

  • Pathways and interactions (According to BioCarta, DIP)

 

                        

  • Protein interactions: LAMC2
  • Clinical                            (According to OMIM, PubMed)